| Cas No.: | 39122-38-8 |
| Chemical Name: | NSC 185058 |
| Synonyms: | NSC 185058 |
| SMILES: | S=C(C1=NC=CC=C1)NC2=NC=CC=C2 |
| Formula: | C11H9N3S |
| M.Wt: | 215.3 |
| Sotrage: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
| Description: | NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1]. |
| In Vitro: | NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1]. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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